Services

Services
In Vivo Models⁺ · IVAP (Intestinal and Vascular Access Port) including hepatic and portal vein administration/ sampling in Dogs, Rabbits, and Rats · Fluoroscopic visualization of formulation disbursement · Real time GI pH monitoring · Normal Dogs, Rabbits, Rats and Mice · Isolated organ perfusion (liver, heart/lung) · Anti-viral efficacy testing in mice		In Vitro Models⁺ · Cell culture (BMEC, Caco-2, MDCK, others) · Animal tissues and monolayers w/ Ussing diffusion chambers · Enzymatic stability · Tumor cell cultures · Anti-HIV efficacy testing In Situ Models · Brain and intestinal perfusion
Drug Sensitivity and Efficacy Testing (in-vivo and in-vitro) · Cytotoxicity (MTT assay) · Apoptosis, necrosis, TUNEL, caspases · Anti-HIV efficacy · Anti-cancer efficacy		Immunotoxicity Evaluation* · Immunological evaluation of Drugs (both Humoral and Cellular), · Immunomodulatory /Immunotoxicity studies · Dermatotoxicity and Sensitization studies
Drug - Transporter Interaction · Absorptive transporters (PepT1, …) · Secretory transporters (Pgp, cMOAT, …)		Analytical testing Bioanalysis using: · IR, GC, GLC, LC-GC, LC-MS/MS*, FACS, GC-MS, HPLC and ELISA · Liquid Scintillation Counting · Column chromatography · Sephadex Gel Filtration · Thin Layer Chromatography
⁺Current models		* May require additional "set-up" time or cooperation from additional departments